XtaLAB Synergy Custom

We realize that standard systems may not fit the needs for every lab, so we also offer XtaLAB Synergy Custom systems for those labs who want to take advantage of dual ports or want to integrate special components, such as ACTOR sample changers. Additionally, for laboratories that want even greater flux we offer custom high flux options like an FR-X based diffraction system.

HPC detector

XtaLAB Synergy Custom systems are configured with a Hybrid Photon Counting (HPC) detector, such as the HyPix-6000HE, PILATUS or EIGER. HPC detectors are ideal for crystallography experiments because they are photon counting detectors that directly detect X-ray photons without the need the intermediate step of converting X-ray photons to light with a phosphor, because they have high dynamic range and fast readout speed, and because they have extremely low noise. Additionally, HPC detectors have an ideal point spread function of a single pixel. These combined features, along with shutterless data collection, means that you can collect more accurate data faster. As a result, the XtaLAB Synergy Custom systems offer outstanding performance for your macromolecular and chemical crystallography experiments.

Dual Port Capability

The XtaLAB Synergy Custom system includes a dual port, microfocus rotating anode generator. With XtaLAB Synergy Custom systems, you can configure to have dual single crystal ports or you can configure the second port with a small angle X-ray scattering system, such as the BioSAXS-2000. Additionally, the XtaLAB Synergy Custom comes in a custom designed enclosure with your choice of table size, to accommodate any accessory equipment, such as an ACTOR system or microscope close to the goniometer. Thus, the versatility offered by the XtaLAB Synergy Custom system provides the most flexibility possible for your single crystal diffraction platform.

Features

  • Customized systems for structural biology utilizing a high flux microfocus source
  • Your choice of VariMax™ confocal double-bounce optics for better spectral purity and beam size to match your sample types
  • Four-circle goniometer to provide completeness and redundancy for your data sets
  • HPC detector with single pixel point spread function and true shutterless data collection
  • Dual ports allow for dual detectors or dual crystallography and SAXS ports
  • Options for in situ crystallography and automated mounting for cryo-protected samples
  • Dual wavelength option - for in-house phasing or dual macro- and small molecule capabilities
Rigaku Oxford Diffraction now offers the HyPix-6000HE Hybrid Photon Counting (HPC) detector. Like all HPCs, the HyPix-6000HE offers direct X-ray photon counting, single pixel point spread function and extremely low noise. The HyPix-6000HE HPC offers a small pixel size of 100 microns, which allows you to better resolve reflections for long unit cells as well as improving reflection profile analysis. The HyPix-6000HE has a high frame rate of 100 Hz, as well as a unique Zero Dead Time mode providing the ultimate in error-free shutterless data collection.
  • Direct photon counting with no phosphor blooming
  • Single pixel point spread function
  • 100 μm x 100 μm pixel size
  • Extremely low noise
  • Frame rate of 100 Hz
  • Electronically gateable
  • Radiation tolerant design
The PILATUS3 R 200K is a hybrid photon counting (HPC) detector designed to achieve the best possible data quality for diffraction experiments. HPC detectors are direct-detection, single-photon counting devices that have essentially no noise and high sensitivity. Moreover, the high dynamic range excellent DQE characteristics for the PILATUS3 R 200K means that they it is well suited for accurately measuring weak reflections alongside very strong reflections - overload corrections and separate scans for weak and strong data are not necessary. The readout time for the PILATUS3 R 200K is 7 msec readout speed, making it capable of true shutterless data collection, thus removing errors associated with shutter open/close and goniometer start/stop events. HPC detectors have revolutionized the way data are collected at synchrotrons and the PILATUS3 R detectors bring those same capabilities to collect the best possible data at home.
Detector PILATUS3 R 200K
Active area 83.8 mm x 70.0 mm
SensorReverse-biased silicon diode array
Dynamic quantum efficiency (Cu-Kα; Mo-Kα)> 98%; > 76%
Dynamic range20-bits
Counting rate per pixel2 x 10⁶ X-ray photons/sec
Readout speed7 msec
Maximum frame rate20 Hz
Point-spread function1 pixel
CoolingAir-cooled
Humidity controlNitrogen or dry air flow
Pixel size172 μm x 172 μm
The PILATUS3 R 300K is a hybrid photon counting (HPC) detector that is desirable by labs who desire the benefits offered by PILATUS detectors combined with 4-circle goniometers, but prefer a larger active area. HPC detectors are direct-detection, single-photon counting devices that have essentially no noise and high sensitivity. Moreover, the high dynamic range excellent DQE characteristics for the PILATUS3 R 300K means that they it is well suited for accurately measuring weak reflections alongside very strong reflections - overload corrections and separate scans for weak and strong data are not necessary. The readout time for the PILATUS3 R 300K is 7 msec readout speed, making it capable of true shutterless data collection, thus removing errors associated with shutter open/close and goniometer start/stop events. HPC detectors have revolutionized the way data are collected at synchrotrons and the PILATUS3 R detectors bring those same capabilities to collect the best possible data at home.
Detector PILATUS3 R 300K
Active area 83.8 mm x 106.5 mm
SensorReverse-biased silicon diode array
Dynamic quantum efficiency (Cu-Kα; Mo-Kα)> 98%; > 76%
Dynamic range20-bits
Counting rate per pixel1 x 10⁷ X-ray photons/sec
Readout speed7 msec
Maximum frame rate20 Hz
Point-spread function1 pixel
CoolingWater-cooled
Humidity controlNitrogen or dry air flow
Pixel size172 μm x 172 μm

CrysAlisPro — User-inspired software for superior data quality

Rigaku Oxford Diffraction systems come complete with CrysAlisPro, our user-inspired data collection and data processing software for small molecule and protein crystallography. Designed around an easy-to-use graphical user interface, CrysAlisPro can be operated under fully automatic, semi-automatic or manual control.

Automatic Crystal Screening

At the heart of CrysAlisPro are the automatic crystal screening, data collection and strategy modules. For a typical crystal, a short pre-experiment lasting less than five minutes is recorded to evaluate crystal quality. From the first frame, CrysAlisPro automatically evaluates the crystal quality and provides the user with information regarding the unit cell, intensity estimation by resolution range and suggested frame exposure times for the full data collection. Additionally, CellCheckCSD (developed with the Cambridge Crystallographic Data Center) helps prevent the collection of known structures by automatically screening the CSD for unit cell matches.

Fastest Strategy Software

CrysAlisPro's sophisticated strategy software automatically calculates the optimal conditions for fast, high quality, complete data collection. All strategies are rapidly calculated based on the specific crystal orientation and unit cell. The user has complete control to optimize the strategy for a wide variety of targets including multiplicity, time and resolution. Strategy calculations are extremely fast and efficient, allowing the user to quickly adapt the data collection conditions for a variety of experiment types, with both Mo and Cu radiation.

Automatic and Concurrent Data Reduction

Data reduction and processing initialize automatically with the start of data collection and employ intelligent routines which tune the parameters to give the best data quality. Processed data are accompanied by real time on-screen feedback of data quality and completeness. CrysAlisPro is programmed for multi-core data processing, meaning rapid results even from the largest data sets.

A Full Complement of Crystallographic Tools
In addition to automatic routines, CrysAlisPro includes a very comprehensive and highly effective range of tools and functions for dealing with non-standard and problematic data. These tools are available through the GUI or from a command line interface, and include:
  • Advanced unit cell finding
  • EwaldPro — Reciprocal lattice viewer
  • Twin data processing
  • Incommensurate data processing
  • Automated high pressure data collection and reduction
  • Face-indexing — with automated shape generation
  • Multi-temperature experiments
  • Powder data collection and processing
  • Precession image generation
  • Axial photos

Software Compatibility

Use CrysAlisPro to import and process frames from synchrotrons and other detector formats. Data is automatically output in HKLF format and quick links interface directly to Olex2, CRYSTALS, WinGX and Jana (for use of SHELX, SIR, Superflip and other programs, where installed). Data files are also easily exported for use in third party data reduction packages including MOSFLM, DENZO and XDS.

How to get CrysAlisPro

The software is freely available to users of Rigaku Oxford Diffraction systems and can be downloaded from our forum. Please register at www.rigakuxrayforum.com. Any queries related to the software may be answered on the forum.

Software Updates

We welcome user feedback and CrysAlisPro is frequently updated with new features inspired by users. In this way, our software is continually improving so that your system always provides data of the highest quality. Visit our forum for more information.


AutoChem

AutoChem is the ultimate productivity tool for chemical crystallography, offering fast, fully automatic structure solution and refinement during data collection. Developed exclusively for Rigaku Oxford Diffraction by the authors of Olex2 (Durham University and OlexSys), AutoChem builds upon the success of our original AutoChem software. Seamlessly integrated as an optional plug-in for CrysAlisPro, AutoChem offers an advanced approach for automatic structure determination, with an even higher rate of success.

AutoChem can work with or without a chemical formula, intelligently using multiple solution programs and typically requiring only partial completeness to solve routine structures. In more difficult cases, AutoChem will make attempts in multiple space groups. A number of refinement options are available; atoms are modeled anisotropically where the data supports it and hydrogen atoms are included in calculated geometric positions. The structure is then re-labeled and refined to completion before a final structure report is generated.

CrysAlisPro displays the structure and key refinement parameters, and provides a link to a full Rigaku Oxford Diffraction’s edition of Olex2 — complete with AutoChem plug-in — which can be launched at any time. Here the user can review all aspects of the refinement, step back to any stage of the process and apply changes as necessary.

ACTOR is a proven commercial solution for automating routine crystal screening and data collection at both synchrotron beam lines and home laboratories. Compatible with almost any goniometer and detector combination, the ACTOR eliminates much of the physical handling of samples required during crystal screening and data collection.
The Rigaku PlateMate is a simple, inexpensive tool for rapid screening of crystals within crystallization plates. The PlateMate supports several different SBS format crystallization plates, though best results are observed using X-ray compatible plates. The PlateMate is quickly installed on Rigaku 4-circle AFC11 partial chi and non-inverted phi goniometers by virtue of the standard IUCr goniometer mount fitting.

(Requires partial chi option for CCD and PILATUS systems. IP systems may require a camera repositioning kit to modify camera angle for proper viewing of crystallization wells)

The EZ Aligner tool allows for safe and remote alignment for VariMax or OptiSAXS optics. As the name implies, the EZ Aligner makes optimization of beam intensities an easy task. Simply set up your pin diode and pinhole, then use the EZ Aligner remote to optimize the beam from a safe place outside the radiation enclosure. Each EZ Aligner remote produces a radio signal strong enough to penetrate enclosure material or from another room. The EZ Aligner kit includes a remote control that communicates to 4 motors attached to optic micrometers to adjust optic rotation and translation.
The XtalCheck system includes software that facilitates both visual and diffraction imaging of crystallization experiments. With the XtalCheck system, one can easily survey many crystallization experiments by eliminating the need to harvest and cryo-cool samples. Moreover, one can perform serial crystallography experiments, by collecting data from multiple crystals, to achieve complete data sets that can be used for structure solution.
The 800 Series Cryostream is the most robust, efficient and user-friendly liquid nitrogen based low temperature system available today. Specific features include a superior laminar flow system, meaning virtually zero risk of icing, extremely quiet running and a fast-start system resulting in a cool-down time to 100K of just 20 minutes.
The Oxford Cobra is the non-liquid nitrogen Cryostream. Combining the efficiency of a Cryostream with the advantages of a non-liquid system, the Cobra offers the ultimate solution for both macromolecular and small molecule crystallography.